Diazoverbindungen und Nitrosamine
نویسندگان
چکیده
منابع مشابه
Nutrition and nitrosamine formation.
Nutrition and the fmmation of N-nitroso compounds N-nitroso compounds are an important group of chemical carcinogens that could be involved in human cancer (Magee, 1982). Only a few examples have been found in food and beverages (Assembly of Life Sciences, 1981) but suitable precursors are common dietary constituents (Assembly of Life Sciences, 1981), and the mildly acidic conditions of the sto...
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Previous studies have shown that a diet high in fat and marginally deficient in lipotropes enhances aflatoxin B] hepatocarcinogenesis and depresses hepatic drug metabolism in rats. In this study we have compared induction of tumors by jV-nitrosodimethylamine, ./V-nitrosodiethylamine, or jV-nitrosodibutylamine in normal or marginally lipotrope-deficient rats fed a high-fat diet. The deficiency s...
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The interest in the carcinogenic and biological actions of N-nitroso compounds arose following the reports of the hepatotoxicity by Freund' and Barnes and Magee2 and ofcarcinogenicity (Magee and Barnes)3 of the simplest nitrosamine: N-nitrosodimethylamine (dimethylnitrosamine) and the subsequent observation of Schoental4 and Druckrey et aP on the carcinogenic action of the nitrosamides: n-methy...
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Baird, W. M.,Dipple, A.,Grover,P. L.,Sims,P. &Brookes,P. (1973) Cancer Res. 33,2386-2392 Booth, J. & Sims, P. (1974~) Biochem. Pharmacol. 23,2547-2555 Booth, J. & Sims, P. (1974b) FEBS Lett. 47,30-33 Booth, J., Keysell, G. R. & Sims, P. (1973) Biochem. Pharmacol. 22,1781-1791 Booth, J., Keysell, G. R., Pal, K. & Sims, P. (1974) FEBS Lett. 43,341-344 Boyland, E. (1950) Biochem. SOC. Symp. 5,4044...
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A number of precautions were taken to ensure the accuracy of the analytical procedures and to avoid artifactual formation of N-nitroso compounds. NDPA (5 ng/g), an NDMA analog which is not normally present in the diets, was added to each powdered sample prior to the vacuum distillation step as an internal (recovery) standard. All reported levels of NDMA and NPYR have been adjusted for the recov...
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ژورنال
عنوان ژورنال: Berichte der deutschen chemischen Gesellschaft
سال: 1894
ISSN: 0365-9496,1099-0682
DOI: 10.1002/cber.189402701102